Since the middle of the 20th century many doctors began to consider high doses of B vitamins as a symptomatic and pathogenetic therapy.
B vitamins are neurotropic. They significantly influence on the processes in the nervous system, for example, metabolism, metabolism of mediators, or transmission of excitation.
Vitamin B1 (thiamine) is involved in nerve impulse conduction; it also provides axonal transport that influences on the regeneration of nervous tissue, modulates the neuromuscular transmission, as well as regulates the excitation of the nerve.
Vitamin B6 (pyrodoxine) is a co-factor for over 100 enzymes. It influences on the structure and function of the nervous tissue and firstly regulates the metabolism of amino acids, thereby ensuring the normalization of protein metabolism; this vitamin also participates in the synthesis of various mediators.
Vitamin B12 is involved in the synthesis of the myelin sheath of the axons of nerve cells. It reduces pain when a peripheral nervous system is damaged.
Combination of high-dose B vitamins in the treatment of acute back pain is safe and effective, as it is confirmed by clinical trials.
In experimental models, the combination of high doses of thiamine, pyridoxine and cyanocobalamin was shown to be able to inhibit the passage of pain impulses at the level of the posterior horns and thalamus, to enhance the effect of norepinephrine and serotonin, and to promote the regeneration of nerve fibers.
There is an assumption that the combination of В vitamins inhibits the synthesis and / or blocks the action of inflammatory mediators.